个人简介
主要从事分子荧光传感、近红外荧光染料和荧光探针在生物标记荧光显微成像中的应用等交叉领域中的研究工作。获授权发明专利6项，作为课题负责人先后主持国家自然科学基金青年基金、天津市自然科学基金青年基金，SCI收录论文70余篇。获得互联网+大赛省级铜奖1项。
个人简历
1.2006.9-2010.6 鲁东大学化学与材料学院，学士学位
2.2010.9-2013.6 天津理工大学材料科学与工程学院，硕士学位
3.2013.9-2017.6 哈尔滨工业大学材料科学与工程学院，博士学位
4.2017.6-2020.5 天津理天津理工大学材料科学与工程学院，博士后
5.2020.5-2022.12 天津理天津理工大学材料科学与工程学院，讲师
6.2022.12-至今 天津理天津理工大学材料科学与工程学院，副教授
科研项目及专利
1.主持完成天津市自然科学基金青年项目，项目号18JCQNJC75900。
2.主持完成国家自然科学基金青年项目，项目号21907075。
3.曾宪顺，刘畅，一种具有大斯托克斯位移的近红外发射氧杂蒽荧光染料制备方法，专利号ZL201710666017.4.
4.曾宪顺，肖志刚，刘畅，何松，一种具有咔唑-罗丹明杂化结构的荧光染料制备方法和应用，专利号ZL201810053917.6.
5.刘畅，宋金鹏，陈阔，李季，曾宪顺，一种用于线粒体定位荧光探针及其制备方法及应用，专利号ZL202110273831.6.
6.刘畅，高启航，曾珍，曾宪顺，一种用于线粒体定位荧光染料及其制备方法，专利号ZL202210518711.2.
科研成果
1.Chang Liu, Xiaojie Jiao, Qing Wang, Kun Huang, Song He, Liancheng Zhao and Xianshun Zeng*, A unique rectilinearly π-extended rhodamine dye with large Stokes shift and near-infrared fluorescence for bioimaging, Chem. Commun., 2017, 53, 10727-10730.
2.Chang Liu, Tong Zhao, Song He, Liancheng Zhao, Xianshun Zeng*, A lysosome-targeting viscosity- sensitive fluorescent probe based on a novel functionalised near-infrared xanthene-indolium dye and its application in living cells, J. Mater. Chem. B, 2020, 8, 8838.
3.Chang Liu, Xiaojie Jiao, Songtao Cai, Song He, Liancheng Zhao, Xianshun Zeng*, Reversible fluorescent probe for visually monitoring the concentration-dependent dynamic correlations among HOCl, H2S, and Ca2+ in neurons, Sensors & Actuators: B. Chemical, 2021, 329, 129213.
4.Chang Liu, Ye Shang, Tong Zhao, Lijuan Liang, Song He, Liancheng Zhao, Xianshun Zeng*, Facile functionalized fluorescein derivative as a reversible fluorescence probe for selective monitor of the redox cycle between hypochlorous acid and cysteine, Sensors & Actuators: B. Chemical, 2021, 348, 130632.
5.Xiao-Bo Wang, Hui-Jing Li*, Chang Liu*, Yun-Xiang Hu, Meng-Chen Li, and Yan-Chao Wu, Simple turn-on fluorescent sensor for discriminating Cys/Hcy and GSH from different fluorescent signals, Anal. Chem., 2021, 93, 2244-2253.
6.Zhiming Wang, Yaye Bian, Chang Liu*, Song He, Liancheng Zhao and Xianshun Zeng*, Mitochondria-targeted fluorescent probe for visualization of exogenous and endogenous methylglyoxal in living cells, Chem. Commun., 2022, 58, 6453-6456.
7.Chang Liu, Huimin Yan, Jianhong Wu, Zhiming Wang, Song He, Liancheng Zhao, Xianshun Zeng, Lysosomes-targeting near-infrared fluorescent probe for the detection of pH in living cells, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 278, 121368.
8.Chang Liu, Qihang Gao, Zhen Zeng, Huan Ding, Huirong Yao, Song He, Liancheng Zhao, Xianshun Zeng*, Construction of novel unsymmetrical rhodamine analogue and its application as nitric oxide probe, Dyes and Pigments, 2023, 220, 111766.
9.Huan Ding, Yuanyuan Wu, Huirong Yao, Song He, Liancheng Zhao, Chang Liu*, Xianshun Zeng*, Evaluation of viscosity in inflammation and ferroptosis process based on a bithiophene-containing hemicyanine dye with diminished solvatochromic effect, Dyes and Pigments, 2023, 214, 111203.
10.Chang Liu, Chuang Feng, Yan Liu, Yuanyuan Wu, Huirong Yao, Song He, Xianshun Zeng*, Construction of a novel NIR-emissive rhodamine derivative for monitoring mitochondrial viscosity in ferroptosis, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 328, 125486.
